| dc.contributor.advisor | Dr. Md Bazlar Rashid | |
| dc.contributor.author | ISLAM, MOST. NAIMA | |
| dc.date.accessioned | 2022-04-23T07:47:50Z | |
| dc.date.available | 2022-04-23T07:47:50Z | |
| dc.date.issued | 2014-12 | |
| dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/636 | |
| dc.description | This study aims to investigate whether organic extracts possess thrombolytic
properties with minimal or no toxicity. Coronary artery thrombosis has been
treated by urokinase (UK), streptokinase (SK) or tissue plasminogen activators (tPA) which are widely used clinical thrombolytic agent for the treatment of severe
or massive deep venous thrombosis, pulmonary embolism, myocardial infarction,
and occluded intravenous or dialysis cannulas. Although UK and SK are widely
used in India, Bangladesh and other developing countries due to lower cost as
compared to other thrombolytic drugs but, the use is associated with high risk of
bleeding intracranial hemorrhage, severe anaphylactic reaction and lacks
specificity. Moreover, these drugs are not used in patients who have undergone
surgery or those with a history of nervous lesions, gastrointestinal bleeding or
hypertension. However, as a result of immunogenicity multiple treatments with
SK in a given patient are restricted. Blood clot or thrombus is a great disorder in
the world. Most of the disease are blood clot, heart stroke, coronary artery block
etc. synthetic drug like streptokinase, urokinase are available in market. These are
expensive and have some side effects. In that situation scientist are searching new
herbal drug which have no side effect and available for people, that’s why my
study was designed to evaluate thrombolytic and bleeding time properties of
tobacco and ajawin extract. | en_US |
| dc.description.abstract | In this present study, the leaves extracts of tobacco leaves and azwain subjected to
the thrombolytic activities were assessed by using human erythrocyte and the
results were compared with standard streptokinase (SK). They have great impact
on bleeding time and clotting time. An experiment was carried out in the
laboratory of the department of physiology and pharmacology, Hajee Mohammad
Danesh Science and Technology University, Dinajpur, during the period of JulyDecember/2014. Some plant and spices were collected from Dinajpur district.
Primarily ethanol extract was prepared from those plant and spices. 20
micropipette was taken filled with 0.5 ml human blood and 3 micropipette was
taken as excess micropipette for control. These two kind of micropipette were
screened for assessment their comparative efficacy of clotted blood lysis. Ethanol
extract was used at a dose of 100 micro ml/ micropipette. Then this micropipette
was incubated at 37 degree centigrade temperature for Ihr 45 minutes. After
incubation I found 4 plant and 2 spices has anticoagulant property. These plant are
tobacco flower, Fern, Arum, Cannabis Tezpata and spices are Jowin and Pesta.
Finally I was experimented with Jowin and tobacco in-vivo thrombolytic and
bleed time property .Bleed time and thrombolytic property was experimented in
laboratory compared with Streptokinase (SK). Streptokinase showed 88.13%
efficacy after treatment on rabbit. Efficacy was recorded by compare among
streptokinase control treated extract. Ethanol jawin (Carum copticum) extract lysis
cloted blood 53.24% and ethanolic tobacco (Nicotiana tabacum) flower extract
lysis cloted blood 46.28%. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | HAJEE MOHAMMAD DANESH SCIENCE AND TECHNOLOGY UNIVERSITY, DINAJPUR. | en_US |
| dc.subject | ETHANOLIC EXTRACT OF Carum copticum | en_US |
| dc.subject | Collection of the plant and spices | en_US |
| dc.subject | Preparation of Ethanol Extract | en_US |
| dc.title | THROMBOLYTIC AND BLEEDING TIME PROPERTIES OF ETHANOLIC EXTRACT OF Carum copticum AND Nicotiana tabbacum | en_US |
| dc.type | Thesis | en_US |
