| dc.contributor.advisor | Dr. Md Bazlar Rashid | |
| dc.contributor.author | HOSSEN, MD. AKTER | |
| dc.date.accessioned | 2022-04-23T03:48:33Z | |
| dc.date.available | 2022-04-23T03:48:33Z | |
| dc.date.issued | 2014-12 | |
| dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/536 | |
| dc.description | Man has many problem for their life. Man has many diseases such as
cardiovascular disease, urogenital disease, nutritional disease etc. When man
affected with cardiovascular or myocardial or cerebral infections. Myocardial or
cerebral infractions are the serious consequences in Atherothrombotic diseases
leading to death and the side effects produced by consecutive use of thrombolytic
agent like t-PA, Urokinase and streptokinase to treat these diseases has become a
global concern. Thrombolytic agents such as tissue plasminogen activator,
urokinase, streptokinase (SK), etc are used to dissolve the already formed clots in
the blood vessels . However, these drugs have certain limitations which cause
serious and sometimes fatal consequences including hemorrhage, severe
anaphylactic reaction, lacked specificity, etc. Moreover, as a result of
immunogenicity multiple treatments with SK in a given patient are restricted.
Methi and ajawin has anticoagulant and thrombolytic property respectively. | en_US |
| dc.description.abstract | An experiment was carried out in the laboratory of the department of physiology
and pharmacology, Hajee Mohammad Danesh Science and Technology
University, Dinajpur, during the period of July-December/2014. Some plant and
spices were collected from Dinajpur district. Primarily ethanol extract was
prepared from those plant and spices. 20 micropipette was taken filled with 0.5 ml
human blood and 3 micropipette was taken as excess micropipette for control.
These two kind of micropipette were screened for assessment their comparative
efficacy of clotted blood lysis. Ethanol extract was used at a dose of 100 micro
ml/ micropipette. Then this micropipette was incubated at 37 degree centigrade
temperature for Ihr 45 minutes. After incubation I found 4 plant and 2 spices has
anticoagulant property. These plant are Fern, Arum, Cannabis Tezpata and spices
are Ajawin and Pesta. Finally I was experimented with Ajawin and Methi in-vitro
thrombolytic and anticoagulant property. Anticoagulant and thrombolytic property
was experimented in laboratory compared with Streptokinase (SK). Streptokinase
showed 100% efficacy after treatment. Efficacy was recorded by compare among
streptokinase control treated extract. Ethanol ajawin extract lysis clotted blood
57.33%. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | HAJEE MOHAMMOD DANESH SCIENCE AND TECHNOLOGY UNIVERSITY, DINAJPUR | en_US |
| dc.subject | Collection and management of Human Blood | en_US |
| dc.subject | Streptokinase (SK) | en_US |
| dc.subject | Different plant extract mixing with cloted blood | en_US |
| dc.subject | Preparation of Ethanol Extract | en_US |
| dc.title | IN-VITRO THROMBOLYTIC AND ANTICOAGULANT ACTIVITY OF ETHANOLIC EXTRACT OF Carum copticum AND Triconella foenum-graecum | en_US |
| dc.type | Thesis | en_US |
