| dc.description.abstract | Circulating Tumor Cell Chip in Breast Cancer for
Theragnosis based on Surface-Enhanced Raman
Spectroscopy
Dissertation Director: Professor Jeong-Woo Choi
Circulating tumor cells (CTCs) are emerging biomarkers, especially in case
of liquid biopsy, and important indicator for prognosis monitoring in case of
personalized anticancer therapy. CTC analysis is a promising diagnostic
method for estimating the risk of metastatic relapse and metastatic
progression in patient with cancer. The basic problem of CTC study is their
extremely low inherent numbers in blood (around one CTC per 10° non
cancerous hematopoietic cells). Hence, before detection or characterization
of CTCs their isolation is important. A subpopulation of CTCs with stemlike behavior are known as stem-like circulating tumor cells (SCTCs). In
recent years stem like cancer cells (SCCs) hypothesis has attracted great
attention in the field of cancer biology. According to the concept, a minor | en_US |
