| dc.description.abstract | The experiment was conducted in the research Laboratory of Biochemistry and
Molecular Biology, Hajee Mohammad Danesh Science and Technology University,
Dinajpur, Bangladesh, during the period January, 2018 to March, 2018 to find out
the analysis of the Proximate composition of L. sibiricus, a herbaceous medicinal
plant and the possible effects of bioactive compounds of Rutin and Quercetin. There
is no information about the proximate composition of L. siribicus. We collected the
sample from two different districts Dinajpur and Nilphamari to observe either it has
any significant differences of proximate composition or not. In the proximate
composition analysis, the Ash, Starch, Fiber, Fat, Protein, Non-reducing sugar
(Sucrose), Invert (Total) sugar, Reducing sugar contents of L. sibiricus in Dinajpur
were found, 12.83±0.942%, 1.122±0.045 mg/100g, 1.122±0.045%, 4.950±0.062%,
19.73±1.616%, 2.150±0.224 mg/100g, 3.393±0.258 mg/100g, 1.246±0.050
mg/100g, respectively, while in the L. sibiricus in Nilphamari these compositions
were found 15.92±0.286%, 2.134±0.043 mg/100g, 22.90±0.145%, 4.790±0.474%,
26.77±0.631%, 1.832±0.153 mg/100g, 4.203±0.136 mg/100g, 2.371±0.048
mg/100g respectively. The Data revealed that proximate compositions, mineral
contents and vitamins can be varied depending on the growing area, soil and
environmental factors. In addition that, we used some bioinformatics tools to
analyze the possible effects of bioactive compounds of L. sibiricus. For this, we
selected two most important bioactive compounds Rutin and Quercetin to know the
interactions in Homo sapiens. Because, we have future plan to use L. siribicus to
control the blood sugar in diabetic patients. Rutin and Quercetin are the two
bioactive compounds which can control or reduce the blood sugar of diabetic
patients. We have applied some recently developed computational tools in this
present study. Our results showed that Rutin and Quercetin have either some
positive or negative interactions with 10 proteins and subsequently these 10 proteins
have been found to interact with 99 other proteins through the application of
bioinformatics tools. All of these proteins are involved in cellular, molecular and
biological functions in human body. | en_US |
