| dc.description | A Thesis
By
AMBIARA
Student ID. 1504014
Session: 2015-16
Semester: January-June, 2016
Submitted to the Department of Physiology &
Pharmacology
Hajee Mohammad Danesh Science and Technology
University, Dinajpur, Bangladesh
In fulfillment of the requirements for the degree of
Master of Science
DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY
HAJEE MOHAMMAD DANESH SCIENCE AND
TECHNOLOGY UNIVERSITY, DINAJPUR0-5200,
BANGLADESH | en_US |
| dc.description.abstract | The present study was undertaken to investigate the antidiabetic effect of
the bitter melon and garlic on alloxan induced diabetes in experimental
rabbits. After acclimatization of the age of 4 months rabbits (New Zealand
white) were randomly assigned into five groups (A, B, C, D and E) and each
group was remained 4 rabbits. Group A was kept for negative control
(without alloxan), Group B was kept for positive control (with alloxan)
treated with alloxan intramuscullarly @75mg /kg body weight, Group C was
treated with bitter melon @250mg/kg body weight orally along with alloxan,
Group D was treated with garlic @750mg/kg body weight orally along with
alloxan, Group E treated with combined at previous doses of bitter melon
and garlic along with alloxan. Over the course of the trial, observations
were recorded for induction of diabetics, blood glucose level, body weight,
packed cell volume, ESR and Hb (Hemoglobin) level after 72 hours of
injection. Blood glucose level were increased significantly (p<0.05) in all
treated groups compared to the negative control group and the highest
induction was recorded in group B treated with alloxan. Body weight was
decreased significantly (p<0.05) in all treated groups and lowest was
recorded in group B which received treatment Alloxan. There was
significant decreased in blood glucose level in all treated group C, D, E
compared to the B group and lowest glucose level was recorded in E
groupwhen treated with combined medicinal herbs and body weight was
increased in all treated group C, D, E compared to the B group and highest
was recorded in D group. PCV level was the highest in group E which was
treated with both garlic and bitter melon compare to the A group. The Hb (
Hemoglobin) gm/dl concentration was the highest in group E which was
treated with both garlic and bitter melon compare to the A group. The study
was revealed that the Hb (Hemoglobin) gm/dl concentration was the highest
in group B treated with alloxan.ESR was highest in group B treated with
alloxan and lowest in group E. The present study reveals that combined
II
treatment with bitter melon and garlic increases body weight and decreases
glucose level without affecting health of rabbits. The results of this study
show that chronic oral administration of a suspension of bitter melon and
garlic is an appropriate dosage may be good alternative as antidiabetic
agent. | en_US |
