| dc.contributor.advisor | Dr. Md. Mahmudul Hasan | |
| dc.contributor.author | KHATUN, MOST. FAYZA | |
| dc.date.accessioned | 2022-05-15T06:11:20Z | |
| dc.date.available | 2022-05-15T06:11:20Z | |
| dc.date.issued | 2019-06 | |
| dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/1476 | |
| dc.description | A THESIS
BY
MOST. FAYZA KHATUN
Registration No.: 1705487
Session: 2017
Semester: January-June, 2019
Submitted to the Department of Physiology & Pharmacology
Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh in
partial fulfillment of the requirements for the degree of
MASTER OF SCIENCE (MS)
IN
PHARMACOLOGY | en_US |
| dc.description.abstract | Chronic arsenic (As) toxicity is a severe disease in men and animals which occurs severely in
Bangladesh. Arsenic contamination in ground water used in drinking is the major concern
because As is present in human and animal food chain. This work was done in quails with a view
to observing the efficacy of spirulina (Spirulina platensis) and vitamin E for prevention of As
toxicity. 60 quails were used in this study and animals were divided into control group (T0), As
treated group (T1), As plus spirulina treated group (T2) and As plus vitamin E treated group (T3).
Each group consists of 15 quails. Quails of T0 group were given normal feed and water and kept
as control. Quails of T1, T2 and T3 were given 100 mg arsenic trioxide/L drinking water daily for
30 days. In addition to arsenic trioxide quails of group T2 and T3 were simultaneously fed with
spirulina @ 1 gm/kg feed and vitamin E @ 400mg /kg body weight up to 30 days respectively.
Five quails from each group (T0, T1, T2 and T3) were sacrificed at 15 days interval in order to
determine haematological parameters. Result showed that in group T1, body weight gain was
minimum, whereas in group T2 and T3 the body weight gain in quails were better. Reduction
of TEC and Hb values were observed in arsenic treated group T1. Whereas in rest groups the
TEC and Hb values were comparatively higher than arsenic treated group. Noticeable change
observed in liver and kindey of As treated group in compare to the control group.
Histopathological changes also observed in liver and kindey of As treated group in compare
to the control group. In conclusion, spirulina and vitamin E have significant effect on body
weight, hematological, postmortem and histopathological changes. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | HAJEE MOHAMMOD DANESH SCIENCE AND TECHNOLOGY UNIVERSITY, DINAJPUR | en_US |
| dc.subject | SPIRULINA | en_US |
| dc.subject | VITAMIN E | en_US |
| dc.subject | ARSENIC INDUCED | en_US |
| dc.title | EFFECT OF SPIRULINA (Spirulina platensis) AND VITAMIN E ON ARSENIC INDUCED TOXICITY IN QUAIL | en_US |
| dc.type | Thesis | en_US |
