| dc.description.abstract | The present study was undertaken to investigate the anti-diabetogenic effect of bitter
melon and mahogany on alloxan induced diabetes in experimental rabbits. The
Newzeland white breed male rabbit at the age of 4 months were randomly assigned into
five groups (T1, T2, T3, T4 and T5) and each group was remind 4 rabbits. Group T1 was
kept for negative control or normal group. The rest of the group (T2, T3, T4 and T5) were
injected with alloxan intramuscularly @ 75mg/kg body weight of rabbit. So group T2
was positive control group for diabetes. Group T3, T4 and T5 was considered for bitter
melon, mahogany and both of them at a dose of 250 mg /kg body weight, 50 mg/kg body
weight and at with combined with previous dose and was considered T3, T4 and T5
respectively. After acclimatization, diabetes was induced in four groups of rabbits (T2,
T3, T4 and T5) by administering alloxan injection in a dose of 75mg/kg body weight
intramuscularly. The suspension of whole fruit was tested for its efficacy in alloxan
induced diabetic rabbits. Over the course of the trial, observations were recorded for
induction of diabetics, blood glucose level, body weight after 72 hours. Blood glucose
level were increased significantly (p<0.05) in all treated groups compared to the control
group and the highest induction was recorded in group T2 treated with alloxan. Body
weight was decreased significantly (p<0.05) in alloxan treated group and lowest was
recorded in group T2 which received alloxan treatment. There was significant decreased
in in blood glucose level in all bitter melon and mahogany treated group (T3, T4, T5)
compared to the T2 group and lowest glucose level was recorded in T5 group when
treated with medicinal herbs and body weight was increased in all treated group T3, T4,
T5 compare to the T2 group and highest was recorded in T5 group while treated with
those. The present study reveals that combined treatment with bitter melon and
mahogany increase body weight and decrease glucose level without affecting health of
rabbits. The results of this study show that chronic oral administration of a suspension of
mahogany seed and bitter melon fruits, an appropriate dosage may be good alternative as
anti-diabetic agent. | en_US |
