Dept. of Physiology & Pharmacology

IMPACT OF FOLLICULAR CYST ON UTERINE INFECTIONS WITH LOCAL IMMUNE REGULATION IN COW

2026-10-06T09:07:51Z

IMPACT OF FOLLICULAR CYST ON UTERINE INFECTIONS WITH LOCAL IMMUNE REGULATION IN COW ALAM, MD. SHAHJAHANUR The present study was aimed to examined the impact of follicular cyst on local immune system. A total 40 reproductive tract sample were collected from abettors. Ovarian follicular cysts are anovulatory follicular formations found in dairy cows. Cysts were thought to be solid objects that remained for a long duration. Uterine swabs were taken from the uterine endometrium and mixed with 10 millilitres of PBS solution for bacterial cell culture. During uterine samples examination, immune cells, such as neutrophils and lymphocytes were found in follicular cystic conditions. The inflammatory response to the level of bacterial contamination is more important than the presence of a specific type of bacteria. The current investigation provided evidence for the localized impact of uterine bacterial contamination on the ovary after parturition. The microbiological analysis of the uterine sample revealed E. coli and Staphylococcus aureus bacteria in the uterus of ovarian follicular cystic disease; whereas, the normal uterus did not exhibit any developing bacteria. Additionally, antibacterial antibiotic sensitivity was conducted to determine the antibiotic sensitivity of the colonized bacteria. It was found that there was no antimicrobial resistance at all. Histopathology of the follicular cystic ovary and uterus were carried out, which contained inflammation and fibrous tissue. A well-developed mucosal immune system in the uterus and ovary maintains local immunity by releasing a multitude of substances that change the way underlying resident immune cells function and provide immunological defense against foreign particles. So, in order to prevent metabolic issues and maximize the ration throughout the peri-partum; health measures should be optimized during parturition and postpartum. IMPACT OF FOLLICULAR CYST ON UTERINE INFECTIONS WITH LOCAL IMMUNE REGULATION IN COW; A THESIS BY MD. SHAHJAHANUR ALAM, Student ID. 1504120, Semester: January- June, 2024, Session: 2022-2023; MASTER OF SCIENCE (MS) IN PHARMACOLOGY, DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY, HAJEE MOHAMMAD DANESH SCIENCE AND TECHNOLOGY UNIVERSITY, DINAJPUR-5200; JUNE, 2024.

EFFECT OF ANAPLASMA INFECTION ON INDUCTION OF STRESS CONDITION IN DAIRY COW

2026-10-06T05:46:50Z

EFFECT OF ANAPLASMA INFECTION ON INDUCTION OF STRESS CONDITION IN DAIRY COW HOSSAIN, MD. ZAKER Present study was aimed to examine the role of Anaplasma infection as stress factor in dairy cow. A total of 20 blood samples were collected from cyclic cow. During blood collection BCS, body temperature were recorded. Blood samples were analyzed for protozoa (Anaplasma) identification. Others were considered as control. Blood samples were further examined to determine the ferritin and C – Reactive Protein (CRP) values as a stress indicator. Results showed that the body temperature and BCS were significantly affected (p<0.01) by the presence of Anaplasma infection. Ferritin as a stress indicator were found significantly elevated and C – Reactive Protein (CRP) level were slightly increased in the Anaplasma positive group but the result was not significant. EFFECT OF ANAPLASMA INFECTION ON INDUCTION OF STRESS CONDITION IN DAIRY COW; A THESIS BY MD. ZAKER HOSSAIN, STUDENT ID: 1604061, SEMESTER: JAN – JUN, 2024, SESSION: 2022-2023; MASTERS OF SCIENCE (MS) IN PHARMACOLOGY, DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY, HAJEE MOHAMMAD DANESH SCIENCE AND TECHNOLOGY UNIVERSITY, DINAJPUR-5200. JUNE, 2024.

COMPARATIVE EVALUATION OF GS-441524 AND GS-5734 (REMDESIVIR) FOR THE TREATMENT OF FELINE INFECTIOUS PERITONITIS DISEASE

2026-10-06T04:55:03Z

COMPARATIVE EVALUATION OF GS-441524 AND GS-5734 (REMDESIVIR) FOR THE TREATMENT OF FELINE INFECTIOUS PERITONITIS DISEASE Attempts have been taken to resolve the symptom manifested in feline infectious peritonitis disease in cats. This study was conducted under the department of physiology and pharmacology to determine the comparative evaluation of GS-441524 and GS-5734 (Remdesivir) for the treatment of feline infectious peritonitis in cats. A total number of 40 cats were affected with feline infectious peritonitis disease. Suspected cats were having clinical symptoms like loss of appetite, weight loss, lameness, dark yellow urine, vomiting, pale color mucosa etc. Therefore, several biochemical tests are available like total protein (TP), albumin, bilirubin, SGPT, SGOT, and alkaline phosphatase (ALP) were performed after a blood sample was collected from the patient. Serum total protein was higher and albumin-globulin (AG) ratio was lower, and the bilirubin was higher the cat is considered as positive for FIP. Then the FIP Ab rapid test was considering as the least confirmation of FIP diagnosis. The FIP Ab rapid test is both the quickest and most accurate approach to diagnosing whether a cat has feline infectious peritonitis (FIP). As a useful side result, we now have a cure for FIP that is widely available. Group A (10 cats) was considered as control, the cats were treated with supportive treatment like antibiotics (doxycycline), steroid and vitamin B-complex. Group B (15 cats) was treated with GS-441524 with the dose of 6mg/kg subcutaneously (s/c) daily for 84 days are effective respectively. Group C (15 cats) was treated with remdesivir (GS-5734) with the dose of 15 mg/kg subcutaneously (s/c) daily for 84 days are effective respectively. Observations were recorded for mortality rate (%), survival rate (%), effects or side effects like diarrhea, vomiting, loss of appetite, allergic reaction etc. According to the observation in group A mortality rate 95-100%, in group B mortality rate 8-12% and in group C mortality rate 18-25%, According to the observation in group A survival rate 5%, in group B survival rate 84-92%, in group C survival rate 75-82%. Compare to other groups, group B shows less side effect (diarrhea, vomiting, loss of appetite, allergic reaction etc.). According to the observation GS-441524 shows better result compared to remdesivir (GS-5734) in the treatment of feline infectious peritonitis disease in cats. COMPARATIVE EVALUATION OF GS-441524 AND GS-5734 (REMDESIVIR) FOR THE TREATMENT OF FELINE INFECTIOUS PERITONITIS DISEASE; A THESIS BY MD SALIM AL-RAZY, Student ID: 1604079, Semester: Jan-June, 2024, Session: 2022-2023, MASTER OF SCIENCE (MS) IN PHARMACOLOGY, DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY, HAJEE MOHAMMAD DANESH SCIENCE AND TECHNOLOGY UNIVERSITY, DINAJPUR-5200; JUNE, 2024.

ROLE OF CHROMIUM SUPPLIMENT ON BLOOD GLUCOSE LEVEL REGULATION IN HEAT STRESSED RABBITS

2026-10-06T04:35:31Z

ROLE OF CHROMIUM SUPPLIMENT ON BLOOD GLUCOSE LEVEL REGULATION IN HEAT STRESSED RABBITS HAFSA, MST. UMME This study was aimed to observed the blood glucose level during heat stress and use of chromium supplement. Tweleve (12) New Zealand white rabbits were collected from Rangpur. Four rabbits per cage in three groups [control (T0), Developed Heat stress (T1) and Developed heat stress with chromium supplement (T2)] were selected randomly and housed in cages for 28 days. Heat stress (38-42)C induced by using Three 200wt clear traditional philips Bulb. Then seven days interval measure blood glucose level, hemoglobin level, WBC count and body weight were measured in laboratory.In this reserch outcome of blood glucose level in the first week were not significant among the groups. But notable changes were recorded in 2nd and 3rd weeks where T1 group glucose level was significantly higher than the control and T2 group respectively. At 4th week heat stress condition and glucose level were more than two times higher than other groups. The result of the hematological examination showed that, 2nd, 3rd & 4th, weeks of the research, hemoglobin is significantly lower in T1 group but higher in control and T2 group. Incase of WBC count, higher in control group and T2 group than T1 group. The body weight is higher in T2 group than control & T1 group. These result of the present study suggested that glucoss level decreased in heat stress by feeding chromium supplement. ROLE OF CHROMIUM SUPPLIMENT ON BLOOD GLUCOSE LEVEL REGULATION IN HEAT STRESSED RABBITS; A THESIS BY MST. UMME HAFSA, REGISTRATION NO: 1604101, SEMESTER: JANUARY- JUNE, SESSION: 2022-2023; MASTER OF SCIENCE (MS) IN PHARMACOLOGY, DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY, HAJEE MOHAMMAD DANESH SCIENCE AND TECHNOLOGY UNIVERSITY, DINAJPUR-5200; JUNE, 2024.